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KMID : 0360320000320030516
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Journal of Korean Cancer Research Association
2000 Volume.32 No. 3 p.516 ~ p.523
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Chemotherapy with Five-Day Continuous Infusion of 5-Fluorouracil (5-FU) Plus Cisplatin for Advanced Gastric Cancer: Significance of 5-FU Concentration Monitoring
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Park Yeon-Hee
Kim Bong-Seog
Ryoo Baek-Yeol
Kim Tae-You
Im Young-Hyuck
Shin Ho-Sang
Kang Yoon-Koo
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Abstract
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Purpose :To investigate the therapeutic effects and toxicities of 5-day continuous infusion of 5-FU plus cisplatin FP chemotherapy in advanced gastric adenocarcinoma and to elucidate the relationship between the pharmacokinetic (PK) parameters and therapeutic outcome.
Materials and Methods :Patients with previously untreated advanced stomach cancer were treated with FP chemotherapy. Plasma concentrations of 5-FU were measured using gas chromatography method for 5 days. Correlation of PK parameters of 5-FU with clinical outcome after FP chemotherapy was studied.
Results : Response rate of FP chemotherapy was 46% (95% C.I.: 30 ∼62%). There was a wide range of difference in the concentration and area under the curve (AUC) of 5-FU from patients to patient. We could find significant differences in AUC of 5-FU between the responders and the non-responders (p<0.05).
Conclusion :We could confirm that FP chemotherapy was effective and tolerable for the treatment of advanced stomach cancer. The monitoring of plasma 5-FU concentration after chemotherapy and the adjustment of subsequent 5-FU dose seems to be necessary to improve the treatment outcome of FP chemotherapy.
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KEYWORD
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Stomach neoplasm, Contrinuous infusion, 5-FU, Pharmacokinetics,
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